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Chondroitin Sulfate Proteoglycans (CSPGs)
- Target
- CSPGs
- Molecular classification
- Proteoglycan, Extracellular Matrix Protein
01
Overview
Chondroitin sulfate proteoglycans (CSPGs) are a family of extracellular matrix molecules characterized by a core protein covalently linked to one or more chondroitin sulfate glycosaminoglycan (GAG) side chains. CSPGs are found in various tissues, including cartilage and the central nervous system, where they play critical roles in structural support and cellular signaling. They are involved in cell adhesion, migration, proliferation, receptor binding, and interaction with other extracellular matrix components. In the CNS, CSPGs regulate axon guidance during development and are upregulated after injury, inhibiting axon regeneration. They also influence synaptic plasticity. CSPGs are implicated in neurological disorders and tumor biology.
- Other names
- Proteoglycan chondroitin sulfate-associated proteinAggrecanVersicanNeurocanNG2BrevicanCD44PhosphacanSMC3CSPG1CSPG2CSPG3CSPG4CSPG7CSPG8
02
Biological functions
Cell adhesionCell migrationCell proliferationReceptor bindingAxon guidanceSynaptic plasticitySkeletal developmentInteraction with extracellular matrix componentsRegulation of axon regeneration
03
Disease associations
Neurological disordersBipolar disorderSchizophreniaADHDNeurodegenerative diseasesSpinal cord injuryCancerMelanoma
04
Safety considerations
Inhibition of axon regeneration after CNS injuryContribution to glial scar formation
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