Chondrolectin (CHODL)

Chondrolectin (CHODL) is a type I transmembrane glycoprotein featuring a carbohydrate recognition domain typical of the C-type lectin family in its extracellular portion[1][2][5]. The protein is perinuclearly localized in cells and is thought to function in motor neuron development, axon growth, and guidance, though its precise biological role in humans remains only partially understood[1][2][5]. Chondrolectin is characterized by carbohydrate and hyaluronic acid binding capacity, and increased expression has been observed to ameliorate motor neuron defects in animal models of spinal muscular atrophy[1][2]. Several transcript variants exist, and the gene is located on human chromosome 21[3]. No clinically approved drugs or well-established pharmacological interventions currently target chondrolectin[2][3][5].

Other names

ChondrolectinCHODLC21orf68Transmembrane protein MT75PRED12FLJ12627UNQ872/PRO1890

No approved or investigational drugs directly target chondrolectin; no established pharmacological mechanisms available