Chondromodulin-1 (CNMD)

Chondromodulin-1 (CNMD) is a glycosylated transmembrane protein, cleaved to yield a secreted mature form with potent effects on cartilage biology and vascularization. Expressed predominantly in avascular regions of cartilage, it stimulates chondrocyte growth and proteoglycan synthesis, while acting as a strong inhibitor of angiogenesis. Its activity is critical for cartilage repair, bone healing (especially under mechanical stress), and homeostasis, and also helps maintain avascular zones in cardiac valves. Chondromodulin-1 deficiency impairs cartilage callus formation, delays angiogenesis, and disrupts normal bone consolidation after injury. It is being studied for its roles in chondrosarcoma, infectious endocarditis, and cardiac valve calcification, with growing interest in its therapeutic potential for orthopedic applications and cardiovascular diseases

Other names

Leukocyte cell-derived chemotaxin 1Chondrosurfactant proteinChondromodulin-1ChondromodulinCHMILECT1CH-SPChM-ICHM-ICHM1BRICD3BRICHOS domain containing 3MYETS1multiple myeloma tumor suppressor 1

Chondromodulin-1 mimetics or gene therapies could increase chondrocyte proliferation or inhibit angiogenesis in cartilage/bone repair