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Chondroprogenitor Cells
- Molecular classification
- Stem cell, Progenitor cell
01
Overview
Chondroprogenitor cells are stem/progenitor cells with the capacity for chondrogenic differentiation, used therapeutically to repair or regenerate damaged cartilage tissue. They are relatively immature precursors committed to the chondrogenic lineage and can be derived from various tissues like articular cartilage, synovium, fat pad, periosteum, and tendon. Unlike mature chondrocytes, they are less prone to hypertrophy after implantation. Clinical applications include cartilage defect repair and TMJ disorders.
- Other names
- Chondrogenic progenitor cellsCartilage progenitor cells
02
Mechanism of action
Cellular therapy promoting cartilage regeneration.
03
Biological functions
ChondrogenesisCartilage repairTissue regenerationExtracellular matrix production
04
Disease associations
Cartilage defectsOsteoarthritisTemporomandibular joint (TMJ) disorders
05
Safety considerations
Heterogeneity among isolated populationsLimited availability/invasiveness of harvestRisk of off-target differentiation
06
Biomarkers
CD105CD73CD44CD90CD166SOX9COL2A1
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