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Target intelligence / Profile preview
Chondrosarcoma-associated gene 1 protein (CSAG1)
- Target
- CSAG1
- Molecular classification
- Other (Tumor antigen, centrosomal-associated protein)
01
Overview
Chondrosarcoma-associated gene 1 protein (CSAG1) is a tumor antigen expressed in chondrosarcomas and certain normal tissues such as testis[1]. CSAG1 localizes to the centrosome and plays a critical role in maintaining the integrity of the mitotic spindle pole by constraining the pericentriolar material, thereby ensuring proper chromosome segregation[2][3]. Its loss leads to abnormal spindle pole formation (multipolar mitosis), especially in cells with defective p53 function, suggesting a specific vulnerability in cancer cells lacking p53. CSAG1 may thus represent a candidate for targeted therapy in select cancers[2][3]. There is no current evidence for approved drugs directly targeting CSAG1, nor is it an established clinical biomarker or therapeutic target as of now.
- Other names
- CSAGECT24.1Cancer/testis antigen 24.1Cancer/testis antigen CSAGECancer/testis antigen family 24, member 1
02
Biological functions
Cell cycleMitosisSpindle pole integrityCentrosome maintenance
03
Disease associations
CancerChondrosarcoma
04
Safety considerations
Potential toxicity due to role in mitosis and cell divisionon-target effects on non-cancer tissues (e.g., testis) possible
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