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Target intelligence / Profile preview
Chondrosarcoma-associated gene family member 2 (CSAG2)
- Target
- CSAG2
- Molecular classification
- Other (Cancer/testis antigen, Drug-resistance related protein)
01
Overview
Chondrosarcoma-associated gene family member 2 (CSAG2) is a protein-coding gene primarily recognized as a cancer/testis antigen, notably expressed in various cancers such as chondrosarcoma. CSAG2 is associated with chemotherapy resistance and is implicated in neoplastic and malignant phenotypes, functioning partially by down-regulating the tumor suppressor p53’s transactivation activity and activating the SIRT1 enzyme. It is identified as a marker for certain cancers and may mediate cellular response to xenobiotic stress, contributing to resistance against drugs like taxol (paclitaxel). The protein’s role in malignancy and drug resistance makes it a candidate therapeutic target, although overcoming chemotherapy resistance remains a therapeutic challenge.
- Other names
- Chondrosarcoma-associated gene 2/3 proteinTRAG3CSAG3ACT24.2TRAG-3Cancer/testis antigen 24.2Taxol resistance-associated gene 3 proteincancer/testis antigen family 24 member 2CSAG3Bchondrosarcoma-associated gene 2/3 protein-like
02
Mechanism of action
Associated with chemotherapy resistance; mechanism appears linked to effect on p53 transactivation and SIRT1 activation
03
Biological functions
Response to xenobiotic stimulusDrug resistanceDown-regulation of p53 transactivation functionActivation of SIRT1Possibly linked to malignant phenotype
04
Disease associations
CancerChondrosarcomaChemotherapy resistance
05
Safety considerations
Drug resistance poses challenge for chemotherapy efficacy in cancersclinical targeting risks include overcoming resistance and potential off-target effects in non-cancerous tissue
06
Interacting drugs
Taxol (paclitaxel) [by name association—no direct drug-target interaction mechanism specified]
07
Biomarkers
Cancer/testis antigen 24.2 (expression used as a marker in some cancers including chondrosarcoma)
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