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Target intelligence / Profile preview
Chordin-like protein 2 (CHRDL2)
- Target
- CHRDL2
- Molecular classification
- Secreted protein, Extracellular matrix-associated protein, Cysteine-rich domain-containing protein, BMP antagonist family
01
Overview
Chordin-like protein 2 (CHRDL2) is a secreted, cysteine-rich protein sharing structural similarity with chordin family members, including a pro-collagen repeat domain. CHRDL2 directly interacts with activin A and is expressed in various tissues. Notably, its differential expression in osteoblasts and increased expression in osteoarthritic cartilage point to roles in skeletogenesis and cartilage regeneration. Mutations or dysregulation have been linked to diseases such as inflammatory bowel disease and agammaglobulinemia[3].
- Other names
- Chordin-like 2CHRDL2
02
Mechanism of action
Binds and modulates activity of human activin A, potentially influencing TGF-β pathway signaling[3].
03
Biological functions
Directly binds human activin A (a member of the TGF-β superfamily)Modulates growth factor signalingDifferential expression during osteoblast differentiationRole in adult cartilage regeneration (upregulated in osteoarthritic joint cartilage)
04
Disease associations
Inflammatory bowel diseaseAgammaglobulinemiaOsteoarthritis (expression upregulated in osteoarthritic cartilage)
05
Safety considerations
None specifically described in current literature. General safety concerns may arise from modulating growth factor pathways.
06
Biomarkers
Upregulation in osteoarthritic cartilage suggests CHRDL2 expression as a potential biomarker for cartilage regeneration and osteoarthritis[3].
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