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Target intelligence / Profile preview
Chorionic gonadotropin subunit beta 3 (CGB3)
- Target
- CGB3
- Molecular classification
- Glycoprotein hormone subunit, Hormone, Other
01
Overview
Chorionic gonadotropin subunit beta 3 (CGB3) is one of several highly homologous genes encoding the beta subunit of human chorionic gonadotropin (hCG), a heterodimeric glycoprotein hormone produced by trophoblastic cells in the placenta during pregnancy[1][2][5][6]. hCG consists of a common alpha subunit (shared with LH, FSH, and TSH hormones) and a unique beta subunit, which imparts biological specificity[2][6]. The CGB3 gene, located on chromosome 19q13.3, encodes a 145-amino acid polypeptide essential for stimulating steroidogenesis, progesterone production, and maternal adaptation to pregnancy[1][2][5]. The beta subunit is also clinically significant as a biomarker for pregnancy and various cancers, and as a therapeutic target or reagent in fertility treatments and certain diagnostic applications[2][6].
- Other names
- Choriogonadotropin subunit betaChorionic gonadotrophin chain betabeta subunit HCGhCG betaCG-betaCGB
02
Mechanism of action
Agonist at luteinizing hormone/chorionic gonadotropin receptor (LH/hCG receptor), thereby stimulating steroid hormone production in the ovaries
03
Biological functions
Hormone activity in pregnancySteroidogenesis stimulationPromotion of angiogenesis in placental developmentProgesterone production by the corpus luteumPreparation and maintenance of endometrium for embryo implantationImmunotolerance at the maternal-fetal interfaceInhibition of myometrial contractions
04
Disease associations
Cancer (notably gestational trophoblastic diseases, testicular and ovarian germ cell tumors)Ectopic pregnancyEndodermal sinus tumorParaneoplastic syndromesOther
05
Safety considerations
Off-target or ectopic expression in cancerPotential confusion or false positive diagnosis in non-pregnant patientsHyperstimulation of ovaries (ovarian hyperstimulation syndrome) with therapeutic use
06
Interacting drugs
Chorionic gonadotropin (hCG, therapeutic and diagnostic uses)
2 more in the full profile.
07
Biomarkers
Elevated beta-hCG for pregnancy confirmationElevated beta-hCG as a tumor marker (e.g., testicular cancer, gestational trophoblastic neoplasia)Monitoring treatment response and recurrence in certain cancers
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