Chorionic somatomammotropin hormone-like 1 (CSHL1)

Chorionic somatomammotropin hormone-like 1 (CSHL1) is a member of the somatotropin/prolactin family of hormones encoded by the *CSHL1* gene on chromosome 17[4][8]. It is primarily expressed in the placenta and is structurally related to other growth hormone and lactogen genes in the same chromosomal cluster[4][8]. CSHL1 is believed to play a role as a novel gestational hormone, possibly compensating for deficiencies in other growth hormone/chorionic somatomammotropin cluster members during gestation[4][5][6]. While considered a protein-coding gene, most CSHL1 transcripts are non-coding or may not produce a secreted protein due to alternative splicing[4].\nThe biological function of CSHL1 is not fully established; it is thought to be involved in regulation of growth, lactation, and fetal metabolism, similar to other placental lactogen hormones, but specific data on functional roles or direct therapeutic targeting is lacking[4][5]. Mutations in related genes within the locus (but not specifically CSHL1) are associated with pregnancy-related diseases such as placental lactogen deficiency and Silver-Russell syndrome[1][4]. There are no known drugs that directly target CSHL1, nor established mechanisms of action for pharmacologic intervention or disease monitoring using CSHL1[4][6].\nCSHL1 is not a well-validated therapeutic target, and much of its function remains putative, with most sources considering it an *endogenous peptide hormone* of unclear physiologic significance in humans[4][6][8].

Other names

Chorionic somatomammotropin hormone like 1CSHL1CSHP1CSLChorionic somatomammotropin-likehCS-LCS-5MGC149868Lactogen-likechorionic somatomammotropin CS-5GHB4growth hormone B4chorionic somatomammotropin hormone-like 1epididymis secretory sperm binding proteingrowth hormone cluster