Choroidal Neovascular Endothelial Cells (CNVECs)

Choroidal neovascular endothelial cells are specialized vascular endothelial cells located in the choroid layer of the eye. These cells play a central role in choroidal neovascularization (CNV), a pathological process characterized by the growth of new blood vessels from the choroid into subretinal spaces, commonly observed in diseases such as age-related macular degeneration (AMD). The targeting strategy involves inducing cell death or dysfunction in choroidal neovascular endothelial cells through a photooxidation reaction using an activated photosensitizer, resulting in the generation of reactive oxygen species and subsequent cellular damage.

Other names

Choroidal neovascular endotheliumCNV endothelial cellsNeovascular endothelial cells (choroidal)Endothelial cells in choroidal neovascularization

Photooxidative damage induced by activated photosensitizer, leading to cell death (apoptosis/necrosis) via reactive oxygen species (ROS) generation.