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Target intelligence / Profile preview
Chromaffin Granule Amine Transporter (CGAT)
- Target
- CGAT
- Molecular classification
- Transporter, Enzyme, Antiporter
01
Overview
The chromaffin granule amine transporter (CGAT), also known as vesicular monoamine transporter 1 (VMAT1), is a membrane protein responsible for packaging monoamine neurotransmitters into secretory vesicles within adrenal chromaffin cells and other aminergic cells. This process is essential for the regulated storage and release of neurotransmitters such as norepinephrine, epinephrine, dopamine, and serotonin. CGAT mediates the active transport of cytosolic monoamines into storage vesicles by exchanging one cationic monoamine with two intravesicular protons, relying on a proton gradient generated by vacuolar-type H+-ATPase. Inhibition of CGAT can lead to depletion of monoamine stores and associated side effects.
- Other names
- Vesicular monoamine transporter 1VMAT1SLC18A1 gene product
02
Mechanism of action
Inhibits vesicular monoamine uptake via competitive or allosteric mechanisms.
03
Biological functions
Neurotransmitter transportMonoamine storageRegulated exocytosisCatecholamine biosynthesis
04
Disease associations
Neurological disordersPsychiatric disordersCardiovascular disease (related to catecholamine dysregulation)Hypertension
05
Safety considerations
DepressionParkinsonismHypotension
06
Interacting drugs
Reserpine
4 more in the full profile.
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