Chromatin accessibility complex protein 1 (CHRAC1)

Chromatin accessibility complex protein 1 (CHRAC1) is a histone-fold protein that functions as an accessory subunit of ATP-dependent chromatin remodeling complexes, such as those involving ISWI/SNF2H and ACF1. CHRAC1 interacts with other histone-fold proteins to form dimers, binding DNA in a sequence-independent manner, and is essential for DNA transcription, replication, and chromatin packaging. Within larger chromatin remodeling complexes, it modulates nucleosome positioning and chromatin accessibility to influence gene expression. In cancer, CHRAC1 overexpression drives cell proliferation and survival, notably by interacting with the transcriptional coactivator YAP in the Hippo signaling pathway, thereby promoting oncogenic transcriptional programs. Its dysregulation is implicated in several cancer types and developmental disorders, indicating both its physiological importance and therapeutic potential[1][2][3][4].

Other names

CHRAC-15CHRAC15CHARC15CHRAC-1YCL1CHARC1DNA polymerase epsilon subunit p15histone-fold protein CHRAC15chromatin accessibility complex 15 kDa proteinHuCHRAC15

Not currently targeted by specific approved drugs. Hypothetical mechanism: inhibition could suppress oncogenic transcription programs (specifically via modulation of YAP-dependent transcription in the Hippo pathway).