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Target intelligence / Profile preview
Chromatin assembly factor 1 subunit B (CHAF1B)
- Target
- CHAF1B
- Molecular classification
- Other, Histone chaperone complex subunit, WD-repeat protein family
01
Overview
Chromatin assembly factor 1 subunit B (CHAF1B) is a protein encoded by the CHAF1B gene in humans and is a component of the chromatin assembly factor-1 (CAF-1) complex. This complex consists of three subunits (p150/CHAF1A, p60/CHAF1B, p48/RBBP4) and is essential for assembling histone octamers onto newly-replicated DNA, facilitating nucleosome formation following DNA replication and during DNA repair. CHAF1B exhibits cell cycle-dependent phosphorylation, is normally localized to the nucleus except during mitosis, and plays roles in DNA replication, chromatin structure maintenance, and possibly DNA repair. Dysregulation or abnormal expression of CHAF1B and related CAF-1 complex members have been implicated in cancer and other disorders associated with genomic instability[1][2][4].
- Other names
- CAF1BCAF-1 subunit BCAF-I 60 kDa subunitCAF-I p60MPHOSPH7MPP7CAF1P60CAF1AM-phase phosphoprotein 7chromatin assembly factor I p60 subunitCAF-1chromatin assembly factor-I p60 subunithuman chromatin assembly factor-I p60 subunit
02
Biological functions
Chromatin assemblyNucleosome assemblyDNA replicationDNA repairCell cycle regulation
03
Disease associations
CancerMyeloid leukemia associated with Down syndromeAttention deficit-hyperactivity disorderOther (general genomic instability)
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