Chromatin remodeling regulator CECR2 (CECR2)

CECR2 is a bromodomain-containing protein that functions as a regulator within ATP-dependent chromatin remodeling complexes, especially the CERF-1 and CERF-5 ISWI complexes, which facilitate DNA access for replication, transcription, and repair. CECR2 binds acetylated and butyrylated lysine residues on histones, thus acting as a histone acetyl-lysine reader. It is essential for neurulation during embryogenesis, inner ear development, and spermatogenesis. Mutations or deletions in CECR2 are linked to Cat Eye Syndrome and have been associated with neurodevelopmental disorders including ASD. The protein also plays a role in DNA repair and apoptosis.

Other names

Cat eye syndrome critical region protein 2KIAA1740CECR2

Drugs targeting CECR2 would be expected to inhibit or modulate its bromodomain–histone acetyl-lysine binding activity, thereby affecting chromatin remodeling and gene expression (no approved drugs currently)