Chromobox protein homolog 6 (CBX6)

Chromobox protein homolog 6 (CBX6) is a transcriptional repressor and chromatin-associated protein that forms part of the Polycomb repressive complex 1 (PRC1)[1][2][3][4]. CBX6 is critical in embryonic stem cells for maintaining pluripotency and preventing spontaneous differentiation by repressing developmental gene programs. It binds chromatin in both canonical and non-canonical PRC1 complexes, functioning via mechanisms distinct from the closely related CBX7. CBX6 recruitment to chromatin is independent of the classic H3K27me3 histone mark, reflecting a unique selectivity for chromatin localization. Functional loss of CBX6 triggers differentiation and downregulation of pluripotency genes. As a biomarker, CBX6 expression is associated with glioblastoma, while its broader roles in cancer and development are still being elucidated[1][2][3][4]. If additional entries or information are needed for specific drug interactions or extended disease roles, a deeper literature review or clinical data search would be required. As of mid-2025, CBX6 remains primarily a molecular regulator and biomarker rather than a direct drug target.

Other names

CBX6Chromobox 6Chromobox protein homolog 6Cbx6CBX6_HUMAN

No drugs established for CBX6 specifically, but general mechanism involves repression via chromatin binding and histone modification. Drugs targeting Polycomb group proteins typically aim to inhibit their transcriptional repression functions, potentially reactivating silenced genes.