Target intelligence / Profile preview

Chromodomain-helicase-DNA-binding protein 1-like (CHD1L)

Target: CHD1L
Molecular classification: DNA helicase, ATP-dependent chromatin remodeler, Transcription factor

Overview

CHD1L is a DNA helicase involved in chromatin remodeling and DNA repair. It plays a critical role in the cellular response to DNA damage by facilitating rapid chromatin relaxation at sites of damage, which is essential for efficient repair processes. It promotes early-stage reprogramming and maintenance of pluripotency in stem cells and regulates epithelial-to-mesenchymal transition (EMT).

Mechanism of action

N/A

Biological functions

DNA repairChromatin remodelingStem cell pluripotency maintenanceEpithelial-to-mesenchymal transition (EMT) regulation

Disease associations

Cancer

Safety considerations

Overexpression promotes cancer progression and metastasis

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