Chromodomain-helicase-DNA-binding protein 3 (CHD3)

Chromodomain-helicase-DNA-binding protein 3 (CHD3) is an ATP-dependent DNA helicase and chromatin remodeler encoded by the CHD3 gene in humans[1][5]. Belonging to the CHD protein family, CHD3 contains chromodomains and ATPase/helicase domains, enabling it to use the energy from ATP hydrolysis to reposition nucleosomes and regulate chromatin structure[1][2][3][7]. As a core component of the NuRD complex, CHD3 plays a critical role in histone deacetylation, transcriptional repression, and developmental gene expression control[2][3]. CHD3 is essential for cell fate determination, embryonic development, and neurodevelopmental processes. Mutations in CHD3 lead to Snijders Blok-Campeau syndrome, characterized by intellectual disability, developmental delays, and distinctive facial features[3][4][5]. CHD3 is also the Mi-2 autoantigen recognized in some cases of dermatomyositis[1]. There are no known approved drugs that directly target CHD3, and genetic alteration of its function may result in unpredictable and potentially severe developmental consequences[3][5].

Other names

Chromodomain helicase DNA binding protein 3CHD-3hZFHMi-2aZFHMi2-alphaMi2-ALPHAATP-dependent helicase CHD3Mi-2 autoantigen 240 kDa proteinZinc finger helicaseSNIBCPSchromodomain-helicase-DNA-binding protein 3