Chromodomain helicase DNA binding protein 9 (CHD9)

Chromodomain helicase DNA binding protein 9 (CHD9) is an ATP-dependent chromatin remodeler and DNA helicase belonging to the CHD subfamily of SF2 helicase proteins. It binds to A/T-rich regulatory DNA regions, acts as a transcriptional coactivator for nuclear receptors (notably PPARA), and plays a role in the remodeling of chromatin structure, thereby regulating gene expression patterns and differentiation programs. Unlike several other CHD family members, CHD9 is not essential for mouse development but shows context- and cell-type-specific gene regulatory roles, influencing transcription, higher-order chromatin organization, and possibly disease states such as cancer and developmental syndromes linked to chromatin regulation[1][2][3][4].

Other names

CHD9KIAA0308KISH2PRIC320AD-013x0008CHD-9CReMMFLJ12178BC022889ATP-dependent helicase CHD9Chromatin-related mesenchymal modulatorChromatin-remodeling factor CHROM1Kismet homolog 2PPAR-alpha-interacting complex protein 320 kDaPeroxisomal proliferator-activated receptor A-interacting complex 320 kDa proteinPPAR{gamma}-interacting cofactor 320 kDaciprofibrate bound protein p240proteinx0008