Chromodomain Y-linked 1B (CDY1B)

Chromodomain Y-linked 1B (CDY1B) is a nuclear protein encoded on the Y chromosome and is expressed specifically in the testis, particularly in late spermatids[1][6]. It contains a chromodomain and a histone acetyltransferase catalytic domain, enabling it to bind methylated histones and acetylate histone H4[1][7]. CDY1B is implicated in chromatin remodeling processes crucial for sperm development: it mediates histone hyperacetylation, which facilitates the replacement of histones by protamines as the principal DNA-packaging proteins in sperm. There are two nearly identical copies of this gene on the Y chromosome; CDY1B refers to the more centromeric copy[1][6]. Although CDY1B is biologically important for male fertility, there is no evidence it is currently a direct therapeutic target or receptor for available or experimental drugs[1][2][4][5][7]. Notes on correctness ("is_incorrect"): - CDY1B is not a recognized therapeutic target or receptor; rather, it is a chromatin-associated enzyme relevant in reproductive biology and genetics. - "CDY1B" is commonly conflated with its paralogs (CDY1, CDY2B), and while it is a gene and protein, it is not a conventional pharmacological or therapeutic "target" (such as a receptor, enzyme targeted by drugs, etc.)[1][2][3][7].

Other names

Chromodomain Y-linked 1BTestis-specific chromodomain protein Y 1BCDY1CDY1ACDYTestis-specific chromodomain protein Y 1Chromodomain protein, Y chromosome, 1, centromericChromodomain protein, Y-linked, 1BTestis-specific chromodomain protein on Y, centromericCDY1B