Chromogranin B (CHGB)

Chromogranin B (CHGB) is a member of the granin family of acidic proteins highly expressed in neuroendocrine cells, where it is the principal matrix protein of secretory vesicles (such as chromaffin and large dense-core granules)[1][2]. It is essential for the biogenesis and regulated secretion of these granules, modulating the storage and release of catecholamines (like adrenaline and noradrenaline). CHGB also exists in both soluble and membrane-bound forms; notably, the membrane-integrated form can assemble into large-conductance, highly selective chloride channels, contributing to anion homeostasis and potentially plasma membrane and granule membrane physiology[2][3]. Beyond trafficking and storage roles, proteolytic processing of CHGB generates bioactive peptides that act in autocrine signaling. Abnormal CHGB expression or function is associated with diseases such as hypertension, neurodegeneration, and psychiatric disorders, making it a protein of interest in neuroendocrine and cardiovascular research[1][2][3]. There are currently no drugs known to clinically target CHGB directly, though research tools like ion channel inhibitors exist for experimental modulation[3].

Other names

Secretogranin-1PE-11GAWK peptideCCB peptideSCG1CgBSgIChromogranin-BSecretogranin Isecretogranin Bsecretogranin-1cgBsgI

Not directly targeted by drugs clinically, but DIDS and similar inhibitors can block its anion channel activity experimentally[3]