Chromosome 1 open reading frame 122 (C1orf122)

Chromosome 1 open reading frame 122 (C1orf122) encodes a cytosolic protein known as ALAESM, which is present in all human tissue cells and is especially highly expressed in the brain, spinal cord, adrenal gland, and kidney[3]. The gene is located at chromosome 1p34.3, contains three exons, and encodes at least two protein isoforms[3]. ALAESM does not contain identified transmembrane domains and is predicted to localize primarily in the cytoplasm, despite having a putative nuclear export signal[3]. The exact biological function of C1orf122 is unknown, but it is predicted to be involved in mitochondrial localization and displays post-translational modification sites such as predicted phosphorylation and glycosylation[3]. There is currently no evidence it functions as a therapeutic target (receptor, enzyme, transporter, etc.), nor are disease roles or drug interactions well-characterized[3][5][6][7]. Its expression pattern suggests potential context-specific function in brain and metabolic tissues, but more research is needed for clarification. Key points: - C1orf122 is a poorly characterized protein-coding gene with broad but mostly moderate tissue expression[3][4][5]. - No enzymatic, receptor, transporter, or classic regulatory (e.g., transcription factor) domains have been reported[3][5][7]. - No drugs or established mechanisms of clinical or pharmacological relevance are described for this gene; it is not currently used as a biomarker nor associated with particular therapeutic safety risks[3][7]. - It is distinct from C1ORF112 (a different gene with proposed roles in DNA repair and cancer), so care should be taken not to conflate the two[1][3].

Other names

C1orf122ALAESMFLJ45459uncharacterized protein C1orf122Protein ALAESM1110065P20RikC530005M16RikC5h1orf122