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Chromosome 1 open reading frame 162 (C1orf162)

Target: C1orf162
Molecular classification: Other (Transmembrane protein; not classified as a receptor, enzyme, transporter, ion channel, or known transcription factor)

Overview

Chromosome 1 open reading frame 162 (C1orf162) is a predicted transmembrane protein encoded by the C1orf162 gene in humans. It is expressed primarily in the bone marrow, lymph node, spleen, lung, fetal liver, and thymus, with predicted nuclear localization and a single conserved transmembrane region[2][4][5]. C1orf162 is not widely characterized functionally but may play a role in hematopoietic or immune tissues given its expression profile. It has been observed to be hypomethylated in instances of gastric cancer, suggesting a possible but unconfirmed disease association[2]. There are no known drugs that target C1orf162, and it is not established as a therapeutic target, nor are there known biomarkers or safety concerns associated with its modulation[2][4].

Other names: C1orf162Transmembrane protein C1orf162MGC24133

Mechanism of action

Not applicable; no drugs known to target this protein.

Biological functions

The specific molecular function is not clearly established.Predicted to localize mainly in the nucleus and contains a conserved transmembrane region[2][4].Expression data suggests a role in hematopoietic/immune tissues, but an exact function is not known[2][5].

Disease associations

Has been reported as hypomethylated in gastric cancer[2].No clear role in other diseases established.

Safety considerations

None known; no drugs or therapeutic interventions described.

Biomarkers

C1orf162 hypomethylation noted in certain gastric cancer cases[2]; not an established biomarker for therapy or patient selection.

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