Chromosome 1 open reading frame 216 (C1orf216)

C1orf216 (chromosome 1 open reading frame 216) is a poorly characterized human protein encoded by the C1orf216 gene (HGNC:26800, NCBI Gene:127703, UniProt Q8TAB5). It is a predicted protein of 229 amino acids with no assigned functional domains strongly associated with canonical target classes. Limited data suggest it is enriched in the cytoplasm and may be expressed most highly in kidney tissue (as shown for other ORF proteins like C11orf96). Protein interaction predictions suggest potential roles in cellular processes such as protein-protein binding, signaling, and ER stress, but these are not experimentally validated. There is no evidence it is a receptor, transporter, enzyme, or target of approved drugs. Its biological function remains unknown, and it is not established in disease pathways or as a therapeutic target. The gene is sometimes referred to as "UPF0500 protein C1orf216," which reflects its UniProt family name for uncharacterized proteins. C1orf216 shares the characteristics of "open reading frame" genes, which are often uncharacterized and lack assigned molecular functions or disease associations. There are no published studies linking C1orf216 directly to any drug, disease, or therapeutic intervention, nor is it a recognized biomarker. Protein interaction databases annotate interactions with other proteins (e.g., TMEM117, E3 ubiquitin ligase) based primarily on prediction algorithms; roles in kidney function and possibly response to cellular stress have been postulated for related ORF proteins (e.g., C11orf96), but this has not been confirmed for C1orf216 itself. There is currently insufficient functional evidence to classify C1orf216 as a standard therapeutic target or to attribute specific molecular or clinical significance.

Other names

FLJ38984UPF0500 protein C1orf216CA216