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Target intelligence / Profile preview
Chromosome 1 open reading frame 74 (C1orf74)
- Target
- C1orf74
- Molecular classification
- Other (protein of unknown function, member of domain of unknown function DUF4504)
01
Overview
C1orf74 encodes a protein of 269 amino acids containing the DUF4504 domain, expressed broadly across human tissues. It is upregulated in lung adenocarcinoma and high expression correlates with unfavorable prognosis. In LUAD cell models, knockdown of C1orf74 inhibits cell proliferation, migration, and invasion, induces cell cycle arrest, and increases autophagy. Mechanistically, C1orf74 positively regulates EGFR/AKT/mTORC1 signaling, affects cyclin D1 expression, and may act as an oncogene, suggesting its potential as a novel cancer biomarker and therapeutic target. Its locus is associated with schizophrenia risk and may interact genetically with the IRF6 gene, linked to congenital diseases. No direct drug interactions or mechanisms of action for approved medicines have been described, and its structural or molecular family is classified as "other" due to an unknown function apart from containing DUF4504.
- Other names
- C1orf74UPF0739 protein C1orf74URLC4FLJ25078Up-regulated in lung cancer 4
02
Biological functions
Cell proliferationCell cycle progressionCell migration and invasionSuppression of autophagyPositive regulation of EGFR/AKT/mTORC1 signaling pathway
03
Disease associations
Cancer (upregulated in lung adenocarcinoma; associated with poor prognosis)Neuropsychiatric disease (locus associated with schizophrenia risk; possible links to Van der Woude syndrome when mutated)
04
Safety considerations
No direct therapeutic safety data (the protein is upregulated in malignancy, so targeting must consider broad expression in normal tissues)
05
Biomarkers
High expression in LUAD associated with poor overall survival and post-progression survival—proposed as a candidate prognostic biomarker
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