Chromosome 10 open reading frame 53 (C10orf53)

Chromosome 10 open reading frame 53 (C10orf53) is a protein encoded by the C10orf53 gene in humans[1][6]. The gene is located on chromosome 10q11.23, spans 30,611 nucleotides, and can generate at least two protein isoforms, the most common being 93 amino acids in length[1]. C10orf53 belongs to an uncharacterized protein family (UPF0728) and is predicted to evolve at a rate intermediate between rapidly and slowly evolving genes[1]. Its expression is tissue-specific, being highly enriched in the testes with minimal levels in organs like the cerebellum, liver, placenta, and trachea[1][5]. Within cells, C10orf53 is majorly cytoplasmic, with some presence in the nucleus and mitochondria. There are known post-translational modifications, including phosphorylation, SUMOylation, and acetylation sites[1]. Currently, the molecular function and biological processes involving C10orf53 are not well characterized. Some studies have identified protein-protein interactions with molecules such as the polymeric immunoglobulin receptor (PIGR), DSCC1, UXT, ZG16B, SPECC1L, MNAT1, and SPTB, hinting at roles in cellular transport, cytoskeletal organization, and possibly transcription regulation[1]. Clinical studies suggest C10orf53 expression strongly correlates with normal spermatogenesis and drops in conditions such as teratozoospermia[1]. There is also evidence implicating C10orf53 as detectable in exosomes from African American prostate cancer patients, though its role is not defined[1]. No drugs are known to target C10orf53, and it is not an established therapeutic target, receptor, enzyme, transporter, or transcription factor[1][6]. Note: - There is a similarly named gene, C11orf53, which has established therapeutic relevance and is known as POU2AF2, a transcription coactivator; C10orf53 is unrelated to this molecule[2]. - No established disease causality, mechanisms of action for targeting, or known interacting drugs for C10orf53 exist in the current literature[1][6].

Other names

UPF0728 protein C10orf53Em:AC069546.1CJ053Q8N6V4