Chromosome 10 open reading frame 95 (C10orf95)

Chromosome 10 open reading frame 95 (C10orf95) is a protein encoded by the C10orf95 gene located at 10q24.32 in humans[2][4]. It is a small, arginine-rich nuclear protein (~24 kDa), showing conserved structure across mammals and some more distant vertebrates, and contains one alpha helix and five beta sheets[2][3]. The protein is primarily involved in pre-mRNA splicing, based on its nuclear localization signals and the functional significance of arginine-rich domains in RNA binding and nuclear processing[2]. C10orf95 interacts with other nuclear and RNA-associated proteins, notably DDX39A (an RNA helicase required for mRNA export) and NUS1 (involved in glycosylation pathways)[2]. It is expressed at low to moderate levels in most tissues, with higher levels in the lung and fetal heart[2]. There are limited data directly implicating C10orf95 in disease, but studies have found altered expression in asthma and a possible variant linked to late-onset Alzheimer’s disease; associations with cancers such as medulloblastoma have also been noted at the gene level[2][4]. There are currently no known drugs targeting this protein and no established role as a therapeutic or diagnostic biomarker[4][5]. C10orf95 remains uncharacterized in terms of precise biological roles and clinical utility; it is not presently a recognized therapeutic target.

Other names

C10ORF95FLJ14280uncharacterized protein C10orf95