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Target intelligence / Profile preview
Chromosome 11 open reading frame 52 (C11orf52)
- Target
- C11orf52
- Molecular classification
- Other (Uncharacterized protein; not classified as receptor, enzyme, transporter, ion channel, transcription factor, or histone-modifying enzyme)
01
Overview
Chromosome 11 open reading frame 52 (C11orf52) encodes a small, uncharacterized nuclear protein of 123 amino acids, mapped to chromosome 11q23.1, and highly expressed in several tissues including thyroid, thalamus, pituitary, and placenta[1]. Despite being annotated as a protein-coding gene, its molecular function remains unclear; recent studies reveal its interaction with proteins involved in cell–cell adhesion (especially desmosomal components) and tyrosine signaling, suggesting roles in cellular signaling and structural organization. C11orf52 is also linked to environmental epigenetic regulation, with site-specific DNA methylation patterns in response to exposures like maternal smoking or bisphenol A. While evidence points towards involvement in cancer (particularly lung cancer) and its relevancy as a biomarker for environmental impacts, there are no drugs or targeted therapies for C11orf52, and it is not categorized as a classic druggable target such as a receptor, enzyme, or transporter[1][2][4].
- Other names
- Chromosome 11 open reading frame 52C11orf52MGC14839FLJ25219Uncharacterized protein C11orf52
02
Mechanism of action
None known (no drugs or inhibitors targeting this molecule are reported)
03
Biological functions
Potential role in cell–cell adhesion (predicted from interaction with desmosomal proteins such as DSG1, DSC1, DSG2, JUP)Signal transduction (predicted; interacts with proteins in tyrosine signaling pathways such as LYN, PTPN11, STAT1, YES1)Possible involvement in Wnt/β-catenin pathway (predicted)Epigenetic regulation (DNA methylation at its locus associated with environmental exposures)
04
Disease associations
Cancer (possible role in lung cancer through aberrant phosphorylation and proliferation)Epigenetic biomarker for response to environmental factors (including maternal smoking and bisphenol A exposure; implications for developmental and disease outcomes)Other (no direct attribution to other diseases in current literature)
05
Safety considerations
None reported (no therapeutics targeting C11orf52)
06
Interacting drugs
None reported
07
Biomarkers
DNA methylation at C11orf52 locus (for environmental exposure, e.g. prenatal tobacco smoke, bisphenol A)
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