Chromosome 11 open reading frame 86 (C11orf86)

Chromosome 11 open reading frame 86 (C11orf86) encodes an uncharacterized protein in humans that is predicted to be localized to the nucleus and to be a member of the DUF4633 superfamily[2]. Its precise molecular function is not established, but it is primarily expressed in gastrointestinal tissues and may play a role in processes such as mammary gland morphogenesis and hormone-level regulation, as inferred from transcriptomics in triple negative breast cancer[1][2]. C11orf86 is 115 amino acids in length, highly arginine-rich, contains several sites for possible post-translational modifications, and does not belong to any well-defined therapeutic target class such as receptor, enzyme, or transporter[2]. The gene is downregulated or shows chromosomal gains in several cancers, and its altered expression may be prognostic in aggressive breast cancer, though it is not yet recognized as a validated drug target or biomarker[1][2]. No specific drugs or mechanisms of action are currently associated with this protein. Existing evidence suggests C11orf86 is not a classic therapeutic target, but it is implicated as a candidate biomarker in oncology research[1][2].

Other names

C11orf86Uncharacterized protein C11orf86FLJ22675FACIFasting and CREB-H inducedENSG00000173237 (Ensembl id)CK086_HUMAN (UniProt protein)