Chromosome 11 open reading frame 96 (C11orf96)

C11orf96 encodes a conserved, cytoplasmic protein of 124 amino acids in humans and other mammals, notable for high serine content and multiple predicted phosphorylation sites, but lacks known transmembrane domains, signal peptides, or well-defined functional domains aside from the DUF4695 domain of unknown function. The protein appears to be widely expressed in mammalian tissues, highest in the kidney in some species, and is upregulated in response to viral infection and stress, potentially indicating roles in cellular stress pathways or as part of broader gene regulatory networks. Protein interaction predictions suggest possible involvement with transmembrane proteins, zinc finger proteins, E3 ubiquitin ligases, and proteins linked to ER stress and gene transcription regulation. Despite these findings, the exact function, biological significance, and disease relevance of C11orf96 remain unknown and subject to further study. There are no established roles in pathogenesis, no approved therapeutics targeting it, and it is not presently considered a validated drug target in any major disease area.

Other names

C11orf96AG2Protein Ag2 homologUncharacterized protein C11orf96Chromosome 11 open reading frame 96

None identified (There are no characterized pharmacological actions or drug mechanisms involving C11orf96.)