Chromosome 11 open reading frame 97 (C11orf97)

Chromosome 11 open reading frame 97 (C11orf97, also known as LINC01171) encodes a short, uncharacterized human protein of 126 amino acids (~13.9 kDa), with predicted localization in the cytoplasm and potential shuttling to and from the nucleus[5]. Its gene is located on chromosome 11q21. The protein features no known transmembrane regions or established protein domains, but is subject to various post-translational modifications including phosphorylation and sumoylation[5][2]. C11orf97 is expressed across many tissues but is most highly detected in several brain regions and lung tissue[5][1]. Evidence from protein-protein interaction data suggests possible roles in cellular stress responses, protein ubiquitination, and transcriptional regulation, although its precise biological function is not well defined[2][5]. Some studies link its potential involvement to rare pathological conditions such as Lemierre’s syndrome and hepatic coma, mainly by association with interacting proteins rather than direct evidence[5]. No therapeutic drugs or biomarker roles have been reported, and there are currently no recognized safety or toxicity concerns. Key points: - The gene is protein-coding and encodes a small, evolutionarily conserved, but uncharacterized protein[1][5]. - Sometimes referenced as LINC01171, it is occasionally annotated as a non-coding RNA but is more accurately described as a protein-coding gene in major databases[1][5]. - It is not established as a therapeutic target, drug target, or direct disease biomarker[1][7]. - Molecular function remains largely unknown; possible indirect disease links are speculative and not well validated[5][8].

Other names

C11orf97LINC01171long intergenic non-protein coding RNA 1171uncharacterized protein C11orf97