Chromosome 11 open reading frame 98 (C11orf98)

Chromosome 11 open reading frame 98 (C11orf98) is a small, uncharacterized protein encoded by a gene on human chromosome 11. The protein is 123 amino acids in length, with a predicted molecular weight of about 14.2 kDa and a basic isoelectric point. It contains a domain of unknown function (DUF5564) and is predicted to be primarily localized in the nucleus. Expression is detected widely across tissues, especially in the lymphatic and immune system organs (appendix, lymph node, thymus), with high mRNA expression also reported in the kidney. Predicted regulatory transcription factors suggest it may have a role in cellular gene expression processes. Protein-protein interaction studies show associations with nuclear and cytoplasmic proteins involved in transcription regulation and cellular signaling, such as c-Jun, fibrillarin, estrogen receptor 1, Scavenger receptor class B member 2, and 2'-5'-oligoadenylate synthetase 3. Its disease associations (Spinocerebellar ataxia 36, Primary hypomagnesemia) are not mechanistically established, and no therapeutic interventions or biomarker applications have been reported. C11orf98 is a protein of unknown function and is not considered a therapeutic target or recognized molecular class like receptor or enzyme. No established drugs, biomarkers, or safety data exist. Disease associations are tentative and not mechanistically understood. Its expression, post-translational modifications, and interactions suggest a possible—but unconfirmed—role in nuclear and gene expression biology.

Other names

C11orf98C11orf48uncharacterized protein C11orf98CK098 proteinLBHD1 (overlapping gene neighbor)