Chromosome 12 open reading frame 42 (C12orf42)

Chromosome 12 open reading frame 42 (C12orf42) is a human gene located at cytogenetic band 12q23.2, encoding a soluble intracellular protein with predicted nuclear localization signals[2]. The protein contains a DUF4607 domain and possibly coiled-coil regions, but its molecular function is uncharacterized. C12orf42 is expressed in various tissues including immune organs (lymph node, spleen, thymus), brain, bladder, epididymis, and helper T cells, suggesting physiological relevance in the nervous, immune, and male reproductive systems[2]. Differential methylation and downregulation have been associated with pancreatic cancer, implicating it as a candidate biomarker, but direct roles in disease pathogenesis or as a drug target have not been established. While it is linked to hereditary pigmentary disorders, no drugs or mechanisms of action are currently attributed to this molecule[4][5].

Other names

C12orf42FLJ25323Uncharacterized protein C12orf42CL042 protein