Chromosome 12 open reading frame 60 (C12orf60)

Chromosome 12 open reading frame 60 (C12orf60) is a human gene encoding an uncharacterized protein, also referred to as LOC144608 or MGC47869, consisting of 245 amino acids and predicted to localize predominantly in the nucleus. The protein lacks transmembrane domains and is rich in alpha-helices, containing a conserved domain of unknown function (DUF4533, pfam15047) shared with very few other gene products. C12orf60 displays regulated expression in human tissues, with highest levels seen in testes and colon, as well as presence in the kidney, certain brain regions, and breast carcinomas. Its biological role remains poorly defined, although protein–protein interaction data suggest possible interactions with bone morphogenetic protein 4 (BMP4) and other proteins, without consensus on functional implications. In the literature, C12orf60 has been identified as a candidate biomarker for monitoring allergen immunotherapy response but is not established as a therapeutic target or drug receptor.

Other names

LOC144608MGC47869uncharacterized protein C12orf60