Chromosome 13 open reading frame 46 (C13orf46)

Chromosome 13 open reading frame 46 (C13orf46) encodes a protein that is present in multiple alternatively spliced isoforms, with the major isoform being 212 amino acids in length. The gene spans approximately 47,563 base pairs and consists of 11 exons. C13orf46 is expressed at low levels across many human tissues, notably including the lungs, stomach, prostate, spleen, and thymus. It does not possess known domains characteristic of common protein families such as receptors, enzymes, transcription factors, or ion channels. Predicted post-translational modifications include phosphorylation, O-GlcNAcylation, mucin-type glycosylation, palmitoylation, and sumoylation. The protein is predicted to be primarily nuclear but may also be present in the cytoplasm or on the cell membrane depending on the isoform. Its molecular structure entails several alpha helices, beta strands, and disordered regions, but it lacks transmembrane domains and classical signal peptides. No functional annotation, disease association, or direct drug interactions are currently established for C13orf46. The neighboring genes are largely non-coding RNAs or regulatory proteins implicated in unrelated pathways (e.g., RASA3 and SWINGN). In summary, C13orf46 is best classified as an uncharacterized human protein with no known functional or clinical relevance to date.

Other names

C13orf46uncharacterized LOC100507747chromosome 13 open reading frame 46

None reported