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Chromosome 15 open reading frame 43 pseudogene (ENSG00000259742) is a non-protein-coding, gene-like DNA sequence highly homologous to a functional gene, but disabled by mutations and incapable of producing a functional protein product. Pseudogenes like this often arise via duplication or retrotransposition events, leading to the accumulation of mutations, loss of regulatory elements, and functional inactivity. Most pseudogenes are transcriptionally silent, although a minority may generate RNA transcripts with potential regulatory effects on cognate genes; however, ENSG00000259742 does not have documented functional transcripts or disease associations.
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