Target intelligence / Profile preview

Chromosome 15 open reading frame 43 pseudogene (ENSG00000259742)

Target
ENSG00000259742
Molecular classification
Pseudogene, Processed pseudogene
01

Overview

Chromosome 15 open reading frame 43 pseudogene (ENSG00000259742) is a non-protein-coding, gene-like DNA sequence highly homologous to a functional gene, but disabled by mutations and incapable of producing a functional protein product. Pseudogenes like this often arise via duplication or retrotransposition events, leading to the accumulation of mutations, loss of regulatory elements, and functional inactivity. Most pseudogenes are transcriptionally silent, although a minority may generate RNA transcripts with potential regulatory effects on cognate genes; however, ENSG00000259742 does not have documented functional transcripts or disease associations.

Other names
C15orf43P
02

Mechanism of action

None.

03

Biological functions

No confirmed function.Possible regulatory role in RNA-mediated processes if transcribed, such as acting as a microRNA decoy or participating in competing endogenous RNA networks, as observed for some pseudogenes. This is general to pseudogenes, not confirmed for ENSG00000259742.
04

Disease associations

None established for this target.In general, some pseudogenes impact disease indirectly by regulating their parental genes, but there is no evidence for this specific pseudogene.

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