Chromosome 15 open reading frame 48 protein (C15orf48)

Chromosome 15 open reading frame 48 protein (C15orf48; also known as NMES1, COXFA4L3, FOAP-11, MOCCI, MISTRAV, and other aliases) is a nuclear-encoded accessory protein of the mitochondrial electron transport chain complex IV (cytochrome c oxidase). It was initially identified due to its reduced expression in esophageal squamous cell carcinoma, and is normally expressed in tissues such as the esophagus, stomach, small intestine, colon, and placenta[2][5]. The protein has been implicated in modulating cytochrome c oxidase activity during inflammation and mitochondrial stress response. While not a classic drug target like a receptor or enzyme, it is associated with disease contexts such as carcinoma and may serve as a biomarker for certain pathologies[5][1]. Notes: - There are no FDA-approved drugs targeting this protein, nor clear mechanisms of action or safety concerns reported in relation to drug targeting[3][5]. - The primary molecular classification is as a mitochondrial complex IV accessory protein, not a channel, receptor, or enzyme. - Biological function data points to a role in inflammation and stress response (reflected by alternate names like MOCCI and MISTRAV)[1][5].

Other names

C15orf48FOAP-11NMES1MIR147BHGCOXFA4L3MOCCIMISTRAVNormal mucosa of esophagus-specific gene 1 proteinMIR147B host geneProtein FOAP-11modulator of cytochrome C oxidase during inflammationmitochondrial stress response antiviral