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Chromosome 15 open reading frame 61 (C15orf61)
- Target
- C15orf61
- Molecular classification
- Other (uncharacterized/unknown function), Predicted mitochondrial protein, DUF4528 domain-containing protein
01
Overview
Chromosome 15 open reading frame 61 (C15orf61) is an uncharacterized human protein-coding gene encoding a 157-amino-acid protein, with predicted mitochondrial localization and a conserved domain (DUF4528)[1][2][3]. This protein is ubiquitously expressed, with relatively higher levels in skeletal muscle, fat, and cerebellar brain tissue[1]. It shows strong evolutionary conservation among mammals and contains a predicted signal peptide, one transmembrane region, and rich histidine/arginine/tryptophan content[1]. Its biological function is incompletely understood but it is thought to be involved in mitochondrial bioenergetics and possibly transcriptional regulation, as it has been correlated with mitochondrial respiratory conductance and shown altered expression in several disease models, including autoimmune diseases, mitochondrial dysfunction, and aging[1][2]. There are no known small-molecule drugs or therapeutics targeting C15orf61, nor is there strong evidence to consider it a classic pharmacological target at this time[1][2][3].
- Other names
- C15orf61CO061_HUMANChromosome 15 open reading frame 61
02
Biological functions
Mitochondrial localization and possible role in mitochondrial bioenergeticsPotentially involved in protein-protein interactions via L27 domainCorrelates with mitochondrial respiratory conductance, possibly functioning as a biomarker or modulator of mitochondrial function under stress
03
Disease associations
Emerging interest in mitochondrial disorders and bioenergetic dysfunctionPotential association with autoimmune disorders (e.g., rheumatoid arthritis, diabetes, multiple sclerosis) based on transcriptional dysregulationCandidate involvement in inflammatory bowel disease (IBD), noted in some studies examining methylation and gene expressionRole as a molecular biomarker in premature aging and hypertrophic cardiomyopathy model systems
04
Biomarkers
Potential biomarker for mitochondrial respiratory capacity and dysfunctionExpression levels may be useful in research settings for mitochondrial stress and respiratory conductance
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