Chromosome 16 open reading frame 78 (C16orf78)

Chromosome 16 open reading frame 78 (C16orf78) encodes a protein of 265 amino acids in humans, with a molecular weight of approximately 30.8 kDa and a predicted isoelectric point of 9.8[1]. The gene is located at 16q12.1 and contains five exons with a single known mRNA transcript[1][4]. Structural predictions suggest an alpha-helical, coiled-coil protein with low-confidence ab initio models and predicted nuclear localization based on the presence of a bipartite nuclear localization signal[1]. Post-translational modifications include verified ubiquitination and phosphorylation sites[1]. C16orf78 protein expression is highly enriched in testis tissue and nearly absent from other tissues[1][5]. Functionally, it has been shown to physically interact with DNA/RNA-binding protein KIN17 and to be phosphorylated by kinases SRPK1 and SPRK2, hinting at a possible role in nuclear processes such as DNA repair[1]. Deletion or mutation in C16orf78 has been found as a genomic determinant in prostate cancer and possibly associated with testicular function and limited evidence connects duplications to Rolandic Epilepsy[1][4]. To date, C16orf78 remains uncharacterized, lacks clear assignment to a classical protein family, and there is no evidence it is an established or actionable therapeutic target[1][4][6].

Other names

Uncharacterized protein C16orf78MGC33367CP078 proteinC16orf78

No drug mechanism established due to lack of therapeutic targeting