Chromosome 16 open reading frame 87 (C16orf87)

Chromosome 16 open reading frame 87 (C16orf87) is a poorly characterized human protein. Proteomic studies identify it as a component interacting with histone deacetylase complexes, including HDAC1 and HDAC2, suggesting a role in chromatin remodeling or epigenetic regulatory mechanisms[2][4][5]. It may act as a novel regulatory factor in the assembly and stabilization of HDAC-containing complexes, potentially affecting transcription, chromatin structure, and early development through modulation of ribonucleoprotein complexes[4][5]. C16orf87 contains a putative zinc-finger domain, hinting at possible DNA-binding activity and involvement in chromatin targeting[2]. The gene has been detected in rare fusion events with ATXN2 in cancer contexts, but no established link to therapeutic targeting, biomarker utility, or direct disease associations has been reported[3].

Other names

C16orf87UPF0547 protein C16orf87CP087_HUMAN[6][4]