Chromosome 16 open reading frame 89 (C16orf89)

Chromosome 16 open reading frame 89 (C16orf89) is a protein-coding gene that chiefly encodes a 361-amino acid, secreted and glycosylated protein with no known functional domains. The gene is predominantly expressed in the thyroid, with expression induced by thyrotropin and detected from embryonic development in both the thyroid and lung, suggesting a potential role in thyroid development and physiology[1][2][3][5][7]. The protein is well conserved among mammals but has no established functional domain or classification. Its expression has also been reported in specific reproductive tissues in animal studies, hinting at undefined roles in reproduction[1]. Recent research has suggested the potential for C16orf89 as a prognostic biomarker in non–small cell lung cancer, as its expression levels are associated with clinical outcomes and inversely correlated with nuclear thymidylate synthase expression[1]. Additionally, epigenetic modifications at the C16orf89 locus have been linked to variations in biomarkers linked to occupational toxicant exposure[1]. No established drugs target C16orf89, and its direct molecular function and involvement in disease mechanisms remain poorly understood[1][2][7].

Other names

C16orf89UPF0764 protein C16orf89UNQ904/PRO1925MGC45438CP089_HUMAN