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Chromosome 17 open reading frame 107 (C17orf107)

Target: C17orf107
Molecular classification: Protein-coding gene, Uncharacterized protein, Other (no established classification as receptor, enzyme, transporter, etc.), Potentially a "ligand-gated ion channel" (classification by gene ontology, pending experimental confirmation)

Overview

Chromosome 17 open reading frame 107 (C17orf107) is a human protein-coding gene located on chromosome 17, encoding an uncharacterized protein. While molecular functions are not yet confirmed, C17orf107 has been associated with certain biological processes such as transport and metabolic regulation, inferred by gene ontology analysis. Its expression is reportedly down-regulated in pancreatic cancer tissue and correlates with poor patient prognosis, indicating utility as a diagnostic and prognostic biomarker for pancreatic cancer[2][3]. The gene is referenced in genetic studies related to congenital myasthenic syndrome, although its mechanistic contribution remains unclear[4]. Due to limited functional data, C17orf107 is currently classified as "other" rather than a defined receptor, enzyme, transporter, or transcription factor. No known therapeutic agents interact with this protein, and its detailed biological role remains to be fully elucidated[3][9][2].

Other names: C17orf107Chromosome 17 open reading frame 107Uncharacterized protein C17orf107HGNC: 37238NCBI Gene: 100130311Ensembl: ENSG00000205710UniProtKB/Swiss-Prot: Q6ZR85

Mechanism of action

Null. No known mechanisms due to lack of identified interacting drugs.

Biological functions

No established biological function.Possible involvement in *glucose metabolic process*, *skeletal muscle contraction*, and *transport*, as suggested by gene ontology and Panther classification.Down-regulated in pancreatic cancer, correlated with poor prognosis.

Disease associations

Pancreatic cancer: *biomarker* and candidate for diagnosis, monitoring, and prognosisMyasthenic syndrome, congenital, 4A and 4B (as an associated gene, based on database listings)

Biomarkers

Expression level of C17orf107 can be used as a *tumor marker* for pancreatic cancer, relevant for early diagnosis, prediction, and prognosis

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