Chromosome 17 open reading frame 58 (C17orf58)

Chromosome 17 open reading frame 58 (C17orf58) encodes a protein also known as UPF0450 protein C17orf58, belonging to the UPF0450 family[3][11]. The gene is protein coding and is located on chromosome 17 in humans[3][5][9]. Its protein is present in the collagen-containing extracellular matrix[3][9], but its precise molecular function and physiological role remain largely uncharacterized[2][3][11]. Currently, no well-defined structural or signaling role, target family, or clear disease mechanism is established for C17orf58; it is not considered a drug target or established biomarker and is not linked to any approved interacting drugs or mechanisms of action[3][11]. It is sometimes associated via genetic studies with complex traits like posterior myocardial infarction and cannabis dependence, but these relationships are not well characterized or clinically validated[3]. The family name UPF0450 reflects its status as a protein of unknown function.

Other names

UPF0450 protein C17orf58CQ058 protein