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Chromosome 19 open reading frame 25 (C19orf25)
- Target
- C19orf25
- Molecular classification
- Other (UPF0449 protein family; not a receptor, enzyme, transporter, or obvious transcription factor)
01
Overview
Chromosome 19 open reading frame 25 (C19orf25) encodes a small, poorly characterized protein belonging to the UPF0449 family, found only in bony vertebrates. It acts as a cytoplasmic protein that participates in the NRZ complex—an evolutionarily conserved multiprotein assembly involved in retrograde traffic from the Golgi apparatus to the endoplasmic reticulum, and potentially has a regulatory or scaffolding function linking vesicle tethering, cell cycle checkpoints, and autophagy. C19orf25 has been shown to physically interact with other trafficking proteins such as USE1 and STING, and its knockout impacts retrograde transport and STING signaling, a pathway relevant to innate immunity. C19orf25 is localized to a genomic region (19p13.3) associated with neurodevelopmental syndromes when deleted, but it is not currently recognized as a direct therapeutic target, nor are there known drugs acting on C19orf25 in the clinic.
- Other names
- C19orf25UPF0449 protein C19orf25FLJ36666hypothetical protein LOC148223CS025_HUMAN
02
Biological functions
Golgi-to-endoplasmic reticulum (ER) retrograde transportRegulation of intracellular vesicle traffickingPotential role in cell cycle regulation and mitotic checkpoint signalingRegulation of STING activation (a protein involved in immune signaling)
03
Disease associations
Neurodevelopmental disease (implicated in microdeletion syndromes at chromosome 19p13.3)Other (no strong direct links to major diseases like cancer or inflammation established)
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