Chromosome 19 open reading frame 48, pseudogene (C19orf48P)

Chromosome 19 open reading frame 48, pseudogene (C19orf48P) is designated as a pseudogene in the human genome and is not believed to encode an active protein product[3][5]. While some database annotations reference "multidrug resistance-related protein," there is no validated evidence that this locus produces a member of the ATP-binding cassette (ABC) transporter family or confers drug resistance activity[5]. The gene is predicted, based on computational analysis, to be involved in RNA processing and possibly to be localized to the nucleolus, but functional validation and protein expression are lacking[2][3]. Pseudogenes like C19orf48P may arise from duplication or mutation of protein-coding genes but are typically transcriptionally inactive or do not encode a functional protein. Despite gene-disease association database entries linking this locus to certain tumors (parathyroid adenoma, ovarian cancer), these are associative and lack evidence for a mechanistic or therapeutic target role[3]. The gene is neither a validated receptor, transporter, enzyme, nor a practical therapeutic target. Key clarification: - The label "multidrug resistance-related protein" is likely a misannotation—there is no evidence that C19orf48P encodes any such protein. Multiple authoritative sources affirm its pseudogene status and lack of molecular function[3][5][2]. - The true multidrug resistance proteins (e.g., MRP1/ABCC1, MRP2/ABCC2, P-glycoprotein/ABCB1, BCRP/ABCG2) are well characterized membrane proteins and are distinct from this locus[1]. If information about multidrug resistance-related proteins (MRP/ABCC family transporters) is actually intended, a different and specific gene locus (such as ABCC1 or ABCC2) should be referenced.

Other names

C19orf48MGC13170BC006151multidrug resistance-related protein (ambiguous/possibly incorrect)