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Chromosome 2 open reading frame 66 (C2orf66) is an uncharacterized human protein predicted to be located in the extracellular region. It is encoded by the *C2orf66* gene at chromosome 2q33.1 and assigned UniProt accession Q6UXQ4. Despite detection in various transcriptomic and proteomic datasets, its biological role and molecular function remain unknown; it lacks evidenced enzymatic activity, receptor properties, or transporter function, and does not belong to major protein families involved in signaling, transport, or transcriptional regulation. No validated disease associations, drug interactions, or biomarker status have been established. The protein is referred to by several recognized aliases, but is not currently highlighted in clinical or therapeutic contexts.
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