Chromosome 2 open reading frame 74 (C2orf74)

Chromosome 2 open reading frame 74 (C2orf74) encodes an uncharacterized human protein found on chromosome 2p15, with two major isoforms generated by alternative splicing[1][5][8]. Isoform 1 is a predicted single-pass transmembrane protein with a domain of unknown function (DUF), predominately helical in structure, and localized to intracellular membranes such as the nuclear membrane, mitochondria, and endoplasmic reticulum[1]. The gene’s expression is generally low, with possible enrichment in brain and colon tissues[1][4]. C2orf74 is conserved in placental mammals and marsupials and is annotated as having protein binding molecular function, suggesting it may be part of molecular complexes rather than an independent effector enzyme or receptor[10]. Disease associations include susceptibility to Crohn’s disease, ankylosing spondylitis, and altered expression in colorectal tumors, most likely through indirect or as-yet-uncharacterized mechanisms[1][5]. No known drugs, direct biomarker utility, or safety concerns are documented, highlighting its poorly defined functional status and absence as a recognized therapeutic target.

Other names

LOC339804uncharacterized protein C2orf74CB074A8MZ97