Chromosome 20 open reading frame 202 (C20orf202)

**Chromosome 20 open reading frame 202** (C20orf202) is a protein-coding gene in humans, encoding a nuclear protein of 122 amino acids primarily expressed in the lung and placenta[2][1]. The protein contains the conserved PFAM domain DUF3461, but its function remains unknown[2][5]. C20orf202 does not belong to any well-defined molecular class such as receptor, enzyme, or transporter, and is currently considered "uncharacterized" with no established biological function or drug interactions[2][1][12][14]. Moderate expression across tissues is noted, with fetal upregulation in kidney, lung, and intestine[2][15]. Its clinical relevance is limited but has been linked by association studies to Twin-To-Twin Transfusion Syndrome, Body Dysmorphic Disorder, and Multiple Sclerosis[1][2]. Protein-protein interaction studies predict binding to SNAPAP and HNRNPCL1, but these do not establish C20orf202 as a therapeutic target or biomarker at present[2].

Other names

Chromosome 20 open reading frame 202C20orf202Uncharacterized protein C20orf202