Chromosome 21 open reading frame 59 pseudogene (C21orf59P)

Chromosome 21 open reading frame 59 pseudogene (C21orf59P, ENSG00000270727) is a nonfunctional genomic DNA sequence located on human chromosome 21 that closely resembles a protein-coding gene but contains disabling mutations such as frameshifts or premature stop codons, preventing production of a functional protein product[1][2][4]. Pseudogenes like this commonly arise from gene duplication or retrotransposition events, and while the majority are biologically inert, some may rarely give rise to regulatory RNA transcripts, but there is currently no evidence that C21orf59P fulfills such a role[4][6]. This pseudogene is not known to be involved in any disease, is not a therapeutic target, does not interact with drugs, and is not used as a biomarker.