Chromosome 22 open reading frame 31 (C22orf31)

Chromosome 22 open reading frame 31 (C22orf31) encodes a protein of 290 amino acids with a predicted molecular mass of 33 kDa and a basic isoelectric point. The protein encompasses a large region identified as “domain of unknown function 4662” (DUF4662), for which neither structure nor specific biological role has been established. C22orf31 shows moderate expression in the testes, low expression in brain and ovaries, and some presence in cancer cell lines. Post-translational modifications such as O-glycosylation, glycation, phosphorylation, and O-GlcNAcylation are predicted. The gene is not associated with well-defined molecular pathways or disease mechanisms, nor is it linked to any known drug interactions or therapeutic targeting. Overall, C22orf31 remains uncharacterized with respect to molecular function and clinical significance.

Other names

C22orf31HS747E2AbK747E2.1chromosome 22 open reading frame 31uncharacterized protein C22orf31