Chromosome 3 open reading frame 33 (C3orf33)

Chromosome 3 open reading frame 33 (C3orf33) encodes a protein that is primarily secreted and thought to participate in transcription regulation, notably through inhibition of the ERK1/ERK2 signaling cascade via an as-yet unidentified receptor on the plasma membrane[2][3][4][11]. The protein is annotated as having some nucleic acid binding and potential hydrolase activity on ester bonds[2], but remains poorly characterized at the molecular level and is not categorized within major receptor, enzyme, transporter, or ion channel families. Its expression is notable in the extracellular space[2][3][4][11], and gene variants are associated with familial temporal lobe epilepsy as well as frontotemporal dementia/ALS, suggesting a possible role in certain neurodegenerative conditions[2]. No drugs currently target C3orf33, and its mechanism of action in disease or therapy remains to be elucidated[2][3][4][11].

Other names

C3orf33AC3-33FLJ31139MSTP052Protein C3orf33Protein AC3-33C3orf33lAP-1 activity suppressorC2h3orf33E130311K13RikRGD1565059RIKEN cDNA E130311K13 gene

Not established. No drugs known to act on C3orf33 or exploit its function/pathway for therapeutic benefit.[2][3][4][11]